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In Vitro Testing of the Protease Modulating Activity of a Nitric Oxide Generating Foam

In a fluorescent assay of five human proteases and one bacterial enzyme, the undiluted NODF components and their 1:1 mixture reduced or eliminated detectable protease activity. The poster reported that inhibition by Solution A and the mixture persisted across the tested dilutions.

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Principal reported finding

What the poster reports

In a fluorescent assay of five human proteases and one bacterial enzyme, the undiluted NODF components and their 1:1 mixture reduced or eliminated detectable protease activity. The poster reported that inhibition by Solution A and the mixture persisted across the tested dilutions.

Program
NODF platform research
Presented at
SAWC Spring & Wound Healing Society Annual Meeting · April 26–30, 2023 · National Harbor, Maryland
Authors
Daniel J. Gibson, PhD

Interpretation

The controlled assay helps characterize effects on wound-relevant proteases and supports the platform’s biological rationale. As laboratory research, it does not establish safety, effectiveness, or clinical outcomes in people.

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