Clinical development
Investigational studies in defined wound populations, reported separately from nonclinical and observational work.
Evidence
Evidence for NOxy’s topical nitric oxide platform.
NOxy’s evidence base spans scientific reviews, laboratory models, clinical development, and retrospective real-world analysis. Each item is labeled by study design so readers can understand what it can—and cannot—show.
Research scope
The largest known body of research focused on topical nitric oxide in wounds.
To our knowledge, NOxy’s program is the largest body of research focused on a topical nitric oxide approach in wounds. It spans scientific reviews, controlled laboratory and tissue models, clinical development, and a 400-patient propensity-matched real-world analysis—one of the largest published pressure-injury and pressure-ulcer studies in older adults. Study design remains attached to every result so each finding can be understood in context.
Real-world observational
Retrospective evidence from care delivered outside randomized studies—useful for patterns, not causal proof.
Ex vivo research
Controlled research in tissue models that can inform biological plausibility without establishing patient outcomes.
In vitro research
Laboratory assays and biofilm models designed to test specific scientific questions under controlled conditions.
Scientific reviews
Peer-reviewed synthesis of published literature and the biological framework for nitric oxide in wound healing.
RetrospectivePropensity-matchedObservational
Published real-world evidence
A real-world analysis of pressure-ulcer healing among older adults.
Sullivan et al. · International Wound Journal · 2026